Excess alcohol consumption also damages the mucous membrane of the digestive tract, resulting in malnutrition. These molecules damage hepatocytes and lead to reactive oxygen species (ROS) production and hangover. Acetaldehyde and nicotinamide adenine dinucleotide (NADH) are produced in the process of alcohol oxidization and are both toxic to the body. However, certain allelic variations in the ALDH2 gene can result in very low enzyme activity, which ultimately leads to acetaldehyde accumulation. Acetaldehyde can be used as an energy source in the body. Acetaldehyde is then oxidized to acetic acid by acetaldehyde dehydrogenase (ALDH). Absorbed alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH). The remaining 10% is excreted through one’s breath, urine, and sweat. This absorbed alcohol is metabolized by the liver. ![]() Alcohol is mainly absorbed in the digestive tract, with up to 30% absorbed in the upper gastrointestinal tract and 60% in the small intestine. However, large doses of alcohol at one time can cause acute intoxication, acute alcoholic hangover, nausea, vomiting, dizziness, headache, and muscle aches. Drinking in moderation can actually help with blood circulation. These findings indicate that CA reduces the serum alcohol concentration and some of the hepatic damage caused by alcohol intoxication.Īlcohol has long been a favorite beverage across the world. At high concentrations of CA, there were no differences in the tested parameters compared to those of normal rats. With regard to most characteristics, we found that CA had dose-dependent effects. In addition, Hepatic histological analyses and stomach wall were demonstrated that the CA-treated group recovered faster than only-ethanol group. The transaminase levels (AST, ALT) in the CA group were significantly lower than only-ethanol group. The activities of alcohol dehydrogenase and acetaldehyde dehydrogenase also recovered faster in the CA group than only-ethanol group. The ethanol and acetaldehyde levels of serum were lower in rats treated with CA than those who only treated ethanol. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute intoxication rats. ![]() ![]() Excessive alcohol consumption induces acute intoxication and various hepatic diseases.
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